Brandilyn Peters
Albert Einstein College of Medicine, NY·Public Health & Epidemiology
Menopause may be harder on women with HIV than on other women. They tend to have stronger symptoms such as hot flashes, lower estrogen levels, and greater declines in heart and blood vessel health.
- Fields
Public Health & Epidemiology
Medicine & Clinical Research
Microbiology & Immunology
- Topics
women with HIV
menopause
menopausal hormone therapy
- Grants
- 1 known grant, through Aug 2027
What they work on
- Determine how 12 weeks of transdermal estradiol, with or without progesterone, changes the gut microbiome of women with HIV in the randomized HoT trial, using shotgun metagenomic sequencing of stool samples.
- Test whether gut microbiome features modify the effect of hormone therapy on serum estradiol levels and vasomotor symptoms such as hot flashes in midlife women with HIV.
- Examine whether the gut microbiome changes how hormone therapy affects cardiovascular markers, including blood pressure and the blood proteins ICAM-1, VCAM-1, D-dimer and fibrinogen.
More about the research
Estrogen-based hormone therapy treats menopause symptoms and can protect the cardiovascular system when started early. The gut microbiome, the community of microbes living in the intestine, helps recycle and retain estrogen in the body. Whether these microbes make hormone therapy work better or worse is unknown.
Why it matters
Women with HIV carry a heavy burden of menopause symptoms and cardiovascular risk. Evidence that gut microbes shape the response to estrogen therapy could guide microbiome-targeted treatments that make hormone therapy work better. These could help women with HIV and possibly other groups of women.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Pauline Maki
Washington University in St Louis, MO·Neuroscience
Map longitudinal changes in brain structure, function, connectivity and memory across menopause stages in 220 women aged 40–59, staging menopause by bleeding criteria and anti-Müllerian hormone (AMH), and relating changes to estradiol.
Ronald J. Ellis
University of California-San Diego, CA·Medicine & Clinical Research
Characterize how gut bacteria and the endocannabinoid system respond to controlled oral THC and CBD in people with and without HIV, using shotgun metagenomic sequencing of stool.
Roberta Eileen Brinton
University of Arizona, AZ·Neuroscience
Test in a Phase 2 double-blind, placebo-controlled trial whether PhytoSERM, a plant-derived estrogen receptor beta (ERβ) modulator, preserves brain glucose metabolism in women with menopausal symptoms, measured by FDG-PET brain scans.
The school
Albert Einstein College of Medicine: 21 labs on PI Pages, $361M a year on research, 36 research doctorates a year.
Reach out
A start for your email. Fill in the brackets.