Vishnu Potluri
University of Pennsylvania, PA·Medicine & Clinical Research·Early-career
Kidney transplants let people with end-stage kidney disease live longer and better lives. Yet who receives a kidney, and how safely, depends on choices made by the transplant system.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
kidney transplantation
end-stage kidney disease
Epstein-Barr virus
- Grants
- 2 known grants, through Apr 2030
What they work on
- Determine whether immunosuppression modifies the risk of post-transplant lymphoproliferative disorder in kidney recipients without prior Epstein-Barr virus infection who receive organs from infected donors, using validated data from an eight-center consortium.
- Characterize how immunosuppression relates to Epstein-Barr virus infection and blood viral DNA levels over time, using latent class analysis to identify distinct infection trajectories.
- Use simulation-allocation modeling to test whether prioritizing EBV-negative donor kidneys for EBV-negative recipients reduces lymphoma risk with acceptable tradeoffs in waiting time and access.
- Compare kidney discard, disparities in access and recipient outcomes across three U.S. allocation eras, from donor service area boundaries to the 250-nautical-mile concentric circle system.
More about the research
Both projects study how allocation rules and post-transplant care can make transplantation fairer and safer. They use national transplant data, multi-center patient data and simulation models of organ allocation.
Why it matters
Kidney transplant recipients, who need lifelong immunosuppression, face high risks of virus-driven cancers. This work could identify immunosuppression strategies and allocation changes that lower the risk of Epstein-Barr virus-associated lymphoma. Its study of geographic allocation rules could also inform policies that reduce discard of donated kidneys and make access fairer for the roughly 95,000 people on the waiting list.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Lisa McElroy
Duke University, NC·Medicine & Clinical Research·Early-career
Quantify how many patients are eliminated during the screening, evaluation and committee decision phases of transplant selection using electronic health record data.
Neda Sattarnezhad Oskouei
Stanford University, CA·Medicine & Clinical Research·Early-career
Characterize multiple sclerosis patient cohorts with proteomic analysis of anti-EBV antibodies and nerve-damage markers, to test how mimicry between EBV proteins such as EBNA1 and the brain protein GlialCAM drives MS.
Kevin M Bennett
Washington University in St Louis, MO·Biomedical Engineering
Validate individual magnetic resonance imaging features against histopathology scores for interstitial fibrosis, glomerulosclerosis, vascular sclerosis and tubular atrophy, using site-directed biopsies taken from imaged locations in discarded human kidneys.
The school
University of Pennsylvania: 90 labs on PI Pages, $2.2B a year on research, 750 research doctorates a year.
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