Jost Klawitter
University of Colorado Denver/Anschutz Medical Campus, CO·Pharmacology
Cannabis is now legal in many places, and many cannabis products, such as concentrates, contain far more tetrahydrocannabinol (THC, the main intoxicating compound) than products of the past. Doctors increasingly see patients who use cannabis.
- Fields
Pharmacology
Chemistry
Medicine & Clinical Research
- Topics
cannabis
marijuana
cannabinoids
- Grants
- 1 known grant, through Jun 2028
What they work on
- Measure cannabinoids such as THC and cannabis terpenes in samples from users at different life stages to assess exposure and drug-drug interactions, and build a biobank of these samples for future research.
- Assess how cannabis use changes the endocannabinoid system, energy metabolism (through metabolomics) and inflammation markers (through lipidomics), to explain differences in benefit or harm across the lifespan.
- Develop and validate methods to estimate an individual's cannabinoid exposure from sparse samples, using population pharmacokinetic and pharmacodynamic (PK/PD) models to relate exposure to health risks and benefits.
More about the research
Yet scientists still know surprisingly little about how the body absorbs and breaks down cannabinoids (cannabis compounds), how they interact with other drugs, or how their effects change with age. A central problem is simply measuring how much cannabis a person has actually been exposed to.
Why it matters
Better ways to estimate a person's cannabis exposure could help doctors and researchers judge the health risks and possible benefits of today's higher-potency products. Understanding drug-drug interactions and age-related differences may inform safer care for patients who use cannabis, from adolescents to older adults, as legalization expands.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Elizabeth Thompson
Duke University, NC·Pharmacology·Early-career
Identify the best-performing population pharmacokinetic model of milrinone, a drug that helps the heart pump, by externally validating existing models against prospectively collected real-world data from an independent group of critically ill infants.
Florin Musteata
Albany College of Pharmacy and Health Sciences, NY·Pharmacology
Build biocompatible microextraction probes from flexible medical-grade metal wires coated with polymers and high-affinity extraction phases, to draw antibody drugs directly from tumors.
Ellen Kraig
University of Texas Health Science Center at San Antonio, TX·Medicine & Clinical Research
Compare drug levels and biological effects of rapamycin and everolimus in healthy adults aged 65–90. A 6-week adaptive dose-finding study will test daily and intermittent dosing in both sexes.
The school
University of Colorado Denver/Anschutz Medical Campus: 41 labs on PI Pages, $766M a year on research, 205 research doctorates a year.
More about University of Colorado Denver/Anschutz Medical Campus
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