Michael A Mooney
Oregon Health & Science University, OR·Psychology
Attention-deficit/hyperactivity disorder (ADHD) often comes with later problems such as depression, conduct problems, substance use and suicidality. It is still unclear why some children with ADHD follow these paths and others do not.
- Fields
Psychology
Genetics
Public Health & Epidemiology
- Topics
attention-deficit/hyperactivity disorder
polygenic scores
gene-environment interaction
- Grants
- 1 known grant, through Nov 2027
What they work on
- Map how inattention, hyperactivity-impulsivity, irritability, executive functioning, vigilance and reward delay discounting co-develop from ages 7–19, using longitudinal data from the Oregon-ADHD-1000 and ABCD cohorts.
- Test how polygenic scores, which sum many small genetic risk effects, combine with family-level exposures and with geospatially coded neighborhood exposures, such as disadvantage and pollution, to predict ADHD trajectories.
- Relate ADHD trajectories and their genetic and environmental influences to adolescent outcomes, including mood and conduct disorders, suicidality, and drug and alcohol use, and check generalizability across the two datasets.
More about the research
A central question is how inherited genetic risk combines with a child's surroundings, both the neighborhood and the family, to shape how symptoms change over time.
Why it matters
Youth with ADHD face higher risks of depression, conduct problems, substance use and suicide. By showing how genetic risk and neighborhood and family exposures together shape ADHD over time, this work could identify modifiable causes and moderators. These could become targets for prevention and treatment that reduce adolescent risk, including suicide risk.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Raquel Gur
University of Pennsylvania, PA·Medicine & Clinical Research
Track psychiatric symptoms and neurocognition over time in about 300 adolescents and young adults with 22q11.2 deletion syndrome, using dimensional measures with a focus on the emergence of psychosis.
Carolina Makowski
University of California-San Diego, CA·Neuroscience·Early-career
Identify behavioral and neuroimaging correlates of eating disorders in youth from the ABCD Study (ages 11–14) and in a clinical sample of adolescent girls in treatment (ages 13–18), using measures of brain shape and whole-brain microstructure.
Pamela Madden
Washington University in St Louis, MO·Psychology
Follow and assess children enrolled at the Washington University site of the ABCD Study with brain imaging, cognitive testing, bioassays and health interviews every two years from age 9–10 into young adulthood.
The school
Oregon Health & Science University: 24 labs on PI Pages, $545M a year on research, 54 research doctorates a year.
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