Yuefeng Huang
Columbia University, NY·Microbiology & Immunology
Pneumonia is the only infectious disease among the top ten causes of death in the United States. Bacterial pneumonia, such as infection with Pseudomonas aeruginosa, causes heavy inflammation and damages the lung's blood vessels.
- Fields
Microbiology & Immunology
Medicine & Clinical Research
Biology
- Topics
immunology
innate immunity
innate lymphoid cells
- Grants
- 1 known grant, through Apr 2029
What they work on
- Define the location and response dynamics of a newly identified group of innate lymphoid cells inside lung blood vessels (vILC3s) during infection, using mouse models, single-cell analysis and 3-D tissue imaging.
- Test whether vILC3s clear Pseudomonas aeruginosa from the lung by releasing the signal CCL4 to recruit bacteria-killing neutrophils, using ILC3-depletion mouse models and CCL4 neutralization.
- Test whether vILC3s promote regrowth of damaged lung blood vessels after infection by releasing CSF1 to expand macrophages, using mouse genetics and in vitro assays.
More about the research
The body therefore needs an immune response that both clears the bacteria and repairs the tissue. Group 3 innate lymphoid cells (ILC3s), immune cells that respond quickly to microbes in tissues, appear to play a part, but how they do so is poorly understood.
Why it matters
Bacterial pneumonia, including infection with Pseudomonas aeruginosa, is a leading cause of death and can leave lasting lung damage. Understanding how a newly identified group of immune cells inside lung blood vessels helps clear bacteria and rebuild vessels could provide a framework for new therapies. Such therapies could help patients fight lung infection and recover lung function afterward.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Samithamby Jeyaseelan
Louisiana State University, LA·Microbiology & Immunology
Determine how the antioxidant regulator Nrf2 affects survival, bacterial clearance and neutrophil accumulation and function during carbapenem-resistant Klebsiella pneumoniae (CRKP) pneumonia in mice.
Ari B Molofsky
University of California-San Francisco, CA·Microbiology & Immunology
Test how early injury-associated myofibroblasts, which depend on TGFβ signaling and macrophages, limit brain lesion size and loss of function in mouse models of brain injury.
Shelton Wright
University of Washington, WA·Microbiology & Immunology·Early-career
Determine the role of gamma-delta T cells, mucosa-enriched T cells that respond rapidly like innate immune cells, in driving lung inflammation during pulmonary melioidosis in vivo.
The school
Columbia University: 89 labs on PI Pages, $1.4B a year on research, 625 research doctorates a year.
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