PIPages
Labs

Lauren Whitehurst

University of Kentucky, KY·Psychology

Heavy drinking and alcohol use disorder (AUD) are rising quickly among women. Yet most research on alcohol's harms has focused on men.

Fields

Psychology

Medicine & Clinical Research

Neuroscience

Topics

alcohol

sleep

polysomnography

Grants
1 known grant, through Aug 2028

What they work on

  1. Test whether women show greater alcohol-induced sleep disruption than men, by giving intravenous alcohol or saline placebo before eight hours of lab sleep recorded with polysomnography in adults aged 21–45.
  2. Determine whether alcohol disrupts women's sleep more in the late luteal phase than in the mid-follicular phase of the menstrual cycle, comparing paired alcohol and placebo lab sessions in each phase.
  3. Test whether estradiol is linked to less, and progesterone to more, alcohol-disrupted sleep, relating hormone levels to lab polysomnography and at-home actigraphy measures.
  4. Track naturalistic sleep and drinking at home over two 5-day periods using actigraphy, daily sleep diaries and alcohol wrist sensors in each menstrual phase.

More about the research

Alcohol makes people sleepy at first, but later in the night it causes frequent awakenings and disrupts rapid eye movement (REM) sleep, the stage linked to dreaming. Women already face higher rates of insomnia, partly because ovarian hormones that shift across the menstrual cycle affect sleep. Women may also be more sensitive to alcohol's effects on sleep. This project asks how sex, menstrual cycle phase and sex hormones shape the way alcohol disrupts sleep.

Why it matters

Alcohol-disrupted sleep may be an overlooked harm of rising heavy drinking among women, and sleep affects thinking, stress and well-being. Knowing how sex and hormone fluctuations change alcohol's effects on sleep could guide interventions to cut drinking and protect sleep in women across their reproductive years.

Known grants

From NIH and NSF research grants. Labs often have other funding we can't see.

Sex and Sex Hormone Factors Influencing Acute Alcohol Effects on Sleep Physiology

NIH · Sep 2023 – Aug 2028

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Michael Arthur Russell

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Test whether TAC sensor features, namely rise rate, peak and rise duration of each day's alcohol curve, predict alcohol-related consequences on individual drinking days, compared with EMA phone self-reports, in 500 young adults.

The school

University of Kentucky: 34 labs on PI Pages, $528M a year on research, 319 research doctorates a year.

More about University of Kentucky

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