Sherrie Khadanga
University of Vermont, VT·Medicine & Clinical Research
After a heart attack or other heart-related hospital stay, many older adults lose strength and stamina that they never fully regain. Cardiovascular disease is the leading cause of disability acquired in hospital among older adults.
- Fields
Medicine & Clinical Research
Physiology
- Topics
cardiac rehabilitation
cardiovascular disease
older adults
- Grants
- 1 known grant, through Jun 2029
What they work on
- Test in a randomized controlled trial whether high-intensity interval training plus high-intensity resistance training improves peak oxygen uptake (VO2peak) and physical function more than standard moderate cardiac rehabilitation exercise.
- Determine whether greater gains in skeletal muscle fiber size and function explain functional improvements from high-intensity training in older cardiac rehabilitation patients.
- Assess the effects of each exercise program at the organ, tissue and cellular levels in a subset of patients to identify what drives improvements in functional capacity.
More about the research
Cardiac rehabilitation (CR), a supervised exercise program, is meant to reverse these losses using moderate continuous aerobic exercise plus moderate weight training. Some patients, however, gain little, partly because moderate training does little to fix the shrinking, weakened muscle that comes with aging and hospitalization.
Why it matters
Older adults recovering from heart disease could regain more fitness and independence if cardiac rehabilitation used a higher-intensity combined aerobic and strength program. If effective, the approach could reduce later disability, improve clinical outcomes, and encourage wider use of high-intensity exercise among healthy older adults and other patient groups.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Pierce Boyne
University of Cincinnati, OH·Medicine & Clinical Research
Determine whether high-intensity interval walking training or moderate-intensity aerobic training safely produces larger, lasting gains in walking capacity in 156 people with chronic stroke, in a 3-site randomized trial.
Maria V. Ivanova
University of California-Berkeley, CA·Medicine & Clinical Research
Test whether high-intensity exercise improves language, cognition, movement and emotional well-being in 110 stroke survivors with aphasia, compared with a matched low-intensity exercise control in a randomized trial.
Linda May
East Carolina University, NC·Physiology
Determine how aerobic, resistance and combined exercise during pregnancy in women with overweight or obesity affect infant heart and metabolic health and growth patterns, compared with infants of non-exercising mothers.
The school
University of Vermont: 16 labs on PI Pages, $246M a year on research, 76 research doctorates a year.
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