Chris Gregory
Medical University of South Carolina, SC·Medicine & Clinical Research
Depression is the most common mental health problem after stroke, and current treatments mostly do not work well. It also gets in the way of recovery, so people with post-stroke depression are often left out of rehabilitation trials and have few treatment options.
- Fields
Medicine & Clinical Research
Neuroscience
Psychology
- Topics
stroke
depression
aerobic exercise
- Grants
- 1 known grant, through Aug 2029
What they work on
- Compare the effects of combined aerobic exercise and repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation method, versus either treatment alone on depressive symptoms in people with post-stroke depression.
- Test whether aerobic exercise enhances the antidepressant effect of rTMS, and whether reducing depression is linked to better post-stroke recovery, including walking.
- Determine how post-stroke depression limits response to rehabilitation and which baseline participant traits relate to treatment response.
More about the research
The project starts from the idea that depression limits how well the brain and body adapt to rehabilitation. It proposes a "virtuous cycle": treating depression could help people respond better to rehabilitation and regain more function.
Why it matters
People who have had a stroke often develop depression, and current treatments help few of them. If combining aerobic exercise with rTMS proves effective, it could give stroke survivors a new way to treat depression that may also improve walking and overall recovery, and could guide rehabilitation design for patients and their families.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Jessica Cassidy
University of North Carolina at Chapel Hill, NC·Neuroscience
Test whether beta-burst repetitive transcranial magnetic stimulation (rTMS), magnetic pulses timed to the brain's 13–30 Hz movement rhythm, increases corticomuscular coherence more at a site inside the brain-muscle circuit than at a decoy site, in adults with chronic stroke.
Zafiris Daskalakis
University of California-San Diego, CA·Medicine & Clinical Research
Compare standard, clustered and sham maintenance rTMS over six months in 75 adults with treatment-resistant depression, testing which best sustains connectivity between the DLPFC and SGC measured by TMS-EEG.
Ying-Hui Chou
University of Arizona, AZ·Neuroscience
Determine whether excitatory or inhibitory rTMS, magnetic pulses delivered through the scalp and aimed at the hippocampus, improves memory more than sham stimulation, in a randomized crossover trial of 60 adults with amnestic mild cognitive impairment.
The school
Medical University of South Carolina: 19 labs on PI Pages, $321M a year on research, 271 research doctorates a year.
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