Mark Goldberg
University of Texas Health Science Center at San Antonio, TX·Neuroscience
Stroke is the leading cause of adult disability, and more than half of survivors live with lasting movement problems. Rehabilitation helps most in the first 3–6 months, but no medical treatment can extend that window or make recovery more complete.
- Fields
Neuroscience
Genetics
Medicine & Clinical Research
- Topics
stroke
neural repair
neuroplasticity
- Grants
- 1 known grant, through Jul 2028
What they work on
- Test whether REST, a protein that silences neural growth genes, limits motor recovery after stroke by selectively inactivating it in motor cortex neurons of transgenic mice using viral vectors.
- Map how REST loss changes corticospinal axon sprouting and new connections in the spinal cord after stroke, using the SpinalTRAQ imaging and analysis platform.
- Measure effects of REST inactivation on motor function with automated behavioral assessment and on developmental plasticity gene programs with single-cell transcriptomics.
More about the research
This project asks whether a built-in brake on brain rewiring limits recovery, and whether releasing it could help.
Why it matters
No medical treatments currently extend or improve recovery after stroke. If removing REST boosts rewiring in mice, REST could become a therapeutic target. Future therapies could lengthen the recovery window and improve rehabilitation for the many stroke survivors living with lasting motor impairments.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
George Smith
Temple University, PA·Neuroscience
Test whether a human CD59–Thy1.1 GPI-anchor chimera, activated by the bacterial toxin intermedilysin, selectively cuts corticospinal tract axons while sparing neighboring neurons and pathways, using histology of immune response, gliosis and myelination.
Elvira Pirondini
University of Pittsburgh, PA·Biomedical Engineering
Identify which nucleus of the motor thalamus, expected to be the ventral laterolateral (VLL) nucleus, most strongly boosts motor cortex responses and muscle responses, using paired stimulation in anesthetized monkeys.
Jessica Cassidy
University of North Carolina at Chapel Hill, NC·Neuroscience
Test whether beta-burst repetitive transcranial magnetic stimulation (rTMS), magnetic pulses timed to the brain's 13–30 Hz movement rhythm, increases corticomuscular coherence more at a site inside the brain-muscle circuit than at a decoy site, in adults with chronic stroke.
The school
University of Texas Health Science Center at San Antonio: 15 labs on PI Pages, $313M a year on research, 149 research doctorates a year.
More about University of Texas Health Science Center at San Antonio
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