Arvind Caprihan
University of New Mexico, NM·Neuroscience
Alzheimer's disease and related dementias (ADRD) often involve more than one cause: damage to blood vessels and inflammation in the brain can add to the plaques and tangles typical of Alzheimer's. Telling these contributions apart in living patients is difficult, and some communities, including rural American Indian and Hispanic/Latino populations in New Mexico, have had little access to advanced brain imaging.
- Fields
Neuroscience
Medicine & Clinical Research
Biomedical Engineering
- Topics
Alzheimer's disease
dementia
vascular contributions
- Grants
- 1 known grant, through Apr 2029
What they work on
- Provide advanced MRI to Alzheimer's center studies, including blood-brain barrier permeability, quantitative T1 and T2 mapping, and cerebrovascular reactivity, alongside the standard SCAN dementia imaging protocol.
- Scan rural American Indian and Hispanic populations in New Mexico with a 1.5-tesla mobile MRI scanner, and start a PET program for imaging amyloid and tau proteins.
- Compare MRI of preserved brains with scans taken before and after death and with tissue histopathology, linking imaging findings to brain tissue changes.
- Evaluate cerebrovascular reactivity as a biomarker and combine MRI, fluid and neuropathology data into composite markers that distinguish early Alzheimer's disease from mixed dementias.
More about the research
This grant supports the Neuroimaging Core of the New Mexico Alzheimer's Disease Research Center, which provides imaging and analysis to the center's studies.
Why it matters
Distinguishing Alzheimer's disease from mixed dementias with vascular causes could improve diagnosis and prognosis. Imaging markers of blood vessel health and combined MRI, fluid and pathology markers could help detect these conditions earlier. A mobile MRI scanner and a new PET program could give underserved rural American Indian and Hispanic communities in New Mexico access to advanced brain imaging for dementia care.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Jonathan McConathy
University of Alabama at Birmingham, AL·Neuroscience
Acquire amyloid-PET and tau-PET scans, which detect hallmark Alzheimer's protein deposits, and MRI scans from UAB Alzheimer's Disease Research Center participants using a simultaneous PET/MRI system.
Hanzhang Lu
Johns Hopkins University, MD·Biomedical Engineering
Develop VICTR MRI, a non-contrast method that measures venous transit time from changes in T1 relaxation, in six major brain veins including the superior sagittal sinus and internal jugular veins.
Tamer Ibrahim
University of Pittsburgh, PA·Biomedical Engineering
Measure small vessel shape, cerebrovascular reactivity (how brain vessels respond to demand) and cerebrospinal fluid flow with 7T MRI in 60 older adults without dementia, comparing amyloid-positive and amyloid-negative people.
The school
University of New Mexico: 27 labs on PI Pages, $355M a year on research, 182 research doctorates a year.
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