Stephanie Tuminello
Icahn School of Medicine at Mount Sinai, NY·Public Health & Epidemiology
People can age at different speeds on the inside. Some bodies show more wear than their birth date would predict.
- Fields
Public Health & Epidemiology
Genetics
Medicine & Clinical Research
- Topics
World Trade Center
WTC responders
biological aging
- Grants
- 1 known grant, through Jun 2027
What they work on
- Test whether World Trade Center exposure accelerates biological aging in male responders, comparing blood DNA methylation clocks such as Horvath, GrimAge and DunedinPACE with unexposed men from the general population.
- Compare epigenetic age estimates in prostate tumor tissue from WTC responders and unexposed men, to see whether tumors show accelerated aging after WTC exposure.
- Examine whether aging-related DNA methylation changes in the blood of cancer-free responders match those in WTC-related prostate tumors, adjusting for important confounders.
More about the research
The rescue and recovery workers who responded to the 2001 World Trade Center (WTC) disaster now have a median age of 60. They also have more age-related illness, including cancer, than expected. This project asks whether WTC exposure has sped up their biological aging.
Why it matters
WTC responders carry an excess burden of cancer and other age-related conditions. Blood biomarkers of accelerated aging could help screen responders for age-related vulnerability. They could also guide aging-focused interventions such as exercise, nutritional supplements, vitamin D, cognitive training or behavioral therapy, improving both prevention and treatment for this group.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Anna Nolan
New York University, NY·Medicine & Clinical Research
Identify firefighters exposed to WTC dust who show chronic over-inflammation, accelerated aging and high circulating autoantibodies, and link these markers to lung function and health measures.
Andres Cardenas
Stanford University, CA·Public Health & Epidemiology
Test whether a 12-month in-home HEPA (high-efficiency particulate air) filter intervention slows epigenetic and proteomic aging clocks in the nasal lining and blood of older former smokers with eosinophilic COPD, using samples from a randomized sham-controlled trial.
Lisa Barcellos
University of California-Berkeley, CA·Public Health & Epidemiology
Develop comprehensive wildfire smoke exposure assignments for all members of a multi-ethnic cohort of about 5,000 East Bay adults sampled during the 2020–2021 wildfire seasons.
The school
Icahn School of Medicine at Mount Sinai: 45 labs on PI Pages, $1.0B a year on research, 62 research doctorates a year.
Reach out
A start for your email. Fill in the brackets.