Gary Wu
University of Pennsylvania, PA·Microbiology & Immunology
The trillions of microbes living in and on the body, known as the microbiome, appear to play a key role in diseases of the digestive tract, liver and pancreas. Studying these diseases requires measuring both the microbes and the human or animal host, and then linking laboratory findings to patients.
- Fields
Microbiology & Immunology
Medicine & Clinical Research
Genetics
- Topics
microbiome
gut microbiota
host-microbial interactions
- Grants
- 1 known grant, through May 2027
What they work on
- Provide analytic services to measure genomics, transcriptomics and metabolomics in both microbes and their mammalian hosts, including FACS, a method that sorts cells by fluorescent labels, and next-generation sequencing.
- Support microbiota research through expanded microbial culture facilities and broader metabolite measurement in partnership with the Penn Metabolomics core.
- Help investigators extend cell and animal model findings into human studies through a human biospecimen repository tracked with a LabVantage information system.
- Maintain annotated clinical data for characterizing inflammatory bowel disease in a REDCap database that researchers can mine with data science support.
More about the research
This grant supports a shared research core that provides those capabilities to investigators in Penn's Center for Molecular Studies in Digestive and Liver Diseases.
Why it matters
By linking measurements of gut microbes with host gene, protein and metabolite data and with annotated patient samples, this core could help researchers find biomarkers for precision medicine in digestive, liver and pancreatic diseases, including inflammatory bowel disease. It could also help them test whether changing the microbiome can prevent or treat these diseases.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Jenessa Winston
Ohio State University, OH·Microbiology & Immunology·Early-career
Test whether daily supplementation with the secondary bile acid ursodeoxycholic acid (UDCA) changes susceptibility to and severity of Clostridioides difficile infection in IL10-knockout colitis mice.
Larry Harshyne
Thomas Jefferson University, PA·Microbiology & Immunology
Provide high-quality, affordable analysis and sorting of cells, biological particles and extracellular vesicles using fluorescence-activated flow cytometers for cancer center researchers.
Zuhair Ballas
University of Iowa, IA·Medicine & Clinical Research
Provide cancer researchers with high-speed cell sorting, multi-parameter analysis and purification of specific cell subsets for basic and translational studies at the Holden Comprehensive Cancer Center.
The school
University of Pennsylvania: 90 labs on PI Pages, $2.2B a year on research, 750 research doctorates a year.
Reach out
A start for your email. Fill in the brackets.