Denise Hasson
New York University, NY·Medicine & Clinical Research·Early-career
Acute kidney injury (AKI), a sudden loss of kidney function, is common in children in the pediatric intensive care unit (PICU). It is linked to more complications and higher death rates.
- Fields
Medicine & Clinical Research
Physiology
Public Health & Epidemiology
- Topics
acute kidney injury
pediatric intensive care
critically ill children
- Grants
- 1 known grant, through Jan 2031
What they work on
- Characterize baseline nutritional status in 200 high-risk pediatric ICU patients using dietary questionnaires, malnutrition screening, arm circumference, skinfold thickness, grip strength and muscle ultrasound, and test whether these risk subtypes predict acute kidney injury.
- Identify blood metabolomic signatures, patterns of small molecules such as amino acids and nutrients, that distinguish critically ill children with and without nutritional risk.
- Test whether metabolomic markers of nutritional risk are associated with the development or progression of acute kidney injury, defined by serum creatinine and urine output criteria.
More about the research
There are no proven ways to prevent or treat AKI, and the known risk factors, such as underlying illness, cannot be changed. This project asks whether a child's nutritional status on arrival in the PICU is a risk factor that could be changed. Injured kidneys shift how they use energy, which can create energy shortfalls, and children with poor nutritional reserves may be especially vulnerable. Earlier metabolomic studies, which measure many small molecules in the blood at once, linked changes in certain amino acids and essential nutrients to AKI in mice and humans. In mice, supplementing those nutrients prevented AKI.
Why it matters
Children in intensive care who develop acute kidney injury currently have no treatment that prevents it. Better tools for spotting nutritional risk, along with blood markers tied to kidney injury, could identify the children most likely to benefit from nutritional support. They could also guide a future trial testing whether targeted supplements prevent new or worsening AKI.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Julie Jaffray
University of California-San Diego, CA·Medicine & Clinical Research·Early-career
Prospectively validate a pediatric hospital-acquired venous thromboembolism (VTE) risk assessment model from the CHAT Consortium, using a case-control design and electronic medical record review.
Javier Neyra
University of Alabama at Birmingham, AL·Medicine & Clinical Research
Develop and validate deep learning models that predict survival without ongoing dialysis at clinically actionable time points for ICU patients on continuous renal replacement therapy, using EHR and CRRT machine time-series data from 9 institutions.
Nisha Bansal
University of Washington, WA·Medicine & Clinical Research
Test whether targeting home systolic blood pressure, rather than pre-dialysis blood pressure, below 140 mmHg reduces dangerous blood pressure drops during dialysis, in a 200-patient two-center crossover randomized trial of hemodialysis patients.
The school
New York University: 72 labs on PI Pages, $1.5B a year on research, 540 research doctorates a year.
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