Ivan Rosado-Mendez
University of Wisconsin-Madison, WI·Biomedical Engineering
More than 1 in 10 babies in the United States is born too early, and doctors still cannot reliably predict when delivery will happen. Before birth, the cervix softens, shortens and opens, and premature changes come before preterm delivery.
- Fields
Biomedical Engineering
Physics
Medicine & Clinical Research
- Topics
preterm birth
cervical remodeling
cervical softening
- Grants
- 1 known grant, through Apr 2030
What they work on
- Optimize S-Doppler, a statistical and deep-learning ultrasound reconstruction method, in calibrated tissue-mimicking phantoms to maximize resolution and contrast when imaging tiny blood vessels.
- Validate S-Doppler's ability to detect cervical microvascular remodeling in pregnant Sprague-Dawley rats, comparing it with microbubble super-resolution ultrasound in living animals and micro-CT of tissue samples.
- Track cervical microvessel changes in pregnant rhesus macaques over time and test how they contribute to cervical softening, using quantitative imaging biomarkers on the same ultrasound probe.
More about the research
How and why this remodeling happens is poorly understood. Blood vessel changes drive remodeling in many tissues, but tiny vessels in the cervix have been hard to image, because ultrasound has lacked the needed resolution and sensitivity.
Why it matters
Preterm birth is common, and survivors can face lifelong health problems. A contrast-free ultrasound method that shows how the cervix's small blood vessels change could add to a toolkit of noninvasive biomarkers, measurable signs of a body's state. These could form a personal "fingerprint" of cervical remodeling, which may eventually support earlier screening and tailored interventions to reduce preterm births.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
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University of Texas Southwestern Medical Center, TX·Biomedical Engineering
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North Carolina State University, NC·Biomedical Engineering
Develop methods to reduce chest-wall effects and optimize data acquisition for lung quantitative ultrasound (LQUS) in human subjects.
Kristin Gerson
University of Pennsylvania, PA·Medicine & Clinical Research
Determine how the polyamines spermidine and spermine modify immune responses in the cervicovaginal space, including inflammasome activation, NF-κB-driven immune mediators, macrophage differentiation and epithelial-immune signaling, using in vitro cell models.
The school
University of Wisconsin-Madison: 91 labs on PI Pages, $1.9B a year on research, 854 research doctorates a year.
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