Adrienne Shapiro
University of Washington, WA·Public Health & Epidemiology
Tuberculosis can be prevented before it ever makes someone sick. People living with HIV and household members of someone with active TB can take a short course of antibiotics — tuberculosis preventive therapy, or TPT — that sharply lowers their risk of illness and death.
- Fields
Public Health & Epidemiology
Medicine & Clinical Research
Microbiology & Immunology
- Topics
tuberculosis
differentiated service delivery
multi-month dispensing
- Grants
- 1 known grant, through Jul 2030
What they work on
- Test whether differentiated service delivery with multi-month dispensing produces higher completion of tuberculosis preventive therapy than clinic standard of care, in a randomized controlled trial among household contacts of people with TB and people with HIV in Kenya.
- Measure the effect of differentiated TPT delivery on TB transmission in households and the surrounding community, combining follow-up testing of contacts with mathematical modeling of transmission.
- Characterize patient and provider preferences, and the barriers and facilitators to completing and implementing TPT, using qualitative research to inform programmatic guidance.
- Evaluate how short-course regimens such as 3HP (twelve weekly doses of isoniazid and rifapentine) and 3HR, which need little laboratory monitoring, perform when delivered in community rather than clinic settings.
More about the research
Guidelines in Kenya and worldwide recommend it, yet most people who should get TPT never receive or finish it, and the gap widened during the COVID-19 pandemic. This project asks whether delivering TPT the way HIV care is now delivered — in the community, with fewer clinic visits — would get more people through a full course.
Why it matters
TB remains a leading infectious killer, and preventive therapy already works — the failure is in getting it to people and helping them finish it. Evidence from this trial could tell Kenyan and global TB programs whether community-based, multi-month delivery raises completion among people with HIV and household contacts, including young children, and whether that translates into less household and community transmission.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Youngji Jo
University of Connecticut, CT·Public Health & Epidemiology·Early-career
Determine how an integrated HIV-noncommunicable disease care model affects clinical outcomes for people living with HIV who have at least one cardiometabolic condition, using Zambia's TASKPEN trial dataset.
Jerrold Ellner
Rutgers University-New Brunswick, NJ·Medicine & Clinical Research
Scout promising early-stage TB diagnostics and develop a stepwise evaluation plan for each, supported by an Analytic Laboratory Core that assesses and optimizes new technologies.
Maunank Shah
Johns Hopkins University, MD·Medicine & Clinical Research
Evaluate the accuracy and consistency of HIV clinical cases and responses generated by PRISM-HIV, a large language model tool that simulates a faculty mentor for case-based learning.
The school
University of Washington: 81 labs on PI Pages, $1.7B a year on research, 694 research doctorates a year.
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