Debajyoti Ghosh
University of Cincinnati, OH·Microbiology & Immunology
Allergic conditions such as atopic dermatitis (eczema) and asthma are rising faster than genetics alone can explain, pointing to environmental causes. Many factors that change allergy risk, such as C-section birth, breastfeeding, antibiotic use and farm exposure, also change which microbes colonize an infant's body.
- Fields
Microbiology & Immunology
Medicine & Clinical Research
- Topics
atopic dermatitis
eczema
asthma
- Grants
- 1 known grant, last ended Oct 2026
What they work on
- Determine whether perinatal dysbiosis, an imbalanced microbial community in early life, makes mice more susceptible to skin-associated allergic diseases by weakening the skin barrier.
- Test whether a Roseomonas mucosa strain from healthy volunteers protects mice from dysbiosis-associated skin barrier dysfunction, possibly by restoring TNF-related epithelial repair.
- Test whether Roseomonas mucosa treatment protects dysbiotic mice from allergic disease triggered by house dust mite allergen.
More about the research
An imbalanced microbial community in the first year of life, called perinatal dysbiosis, has been linked to higher allergy risk. Allergic diseases also involve a weakened skin or airway barrier. This project asks whether early-life dysbiosis weakens the skin barrier and thereby sets the stage for skin-linked allergies.
Why it matters
Atopic dermatitis and asthma affect a growing number of children. Showing that early-life microbial imbalance damages the skin barrier could help explain this rise. If a topical treatment with a beneficial Roseomonas mucosa strain protects the barrier in mice, it could support microbe-based approaches to lower the risk of skin-associated allergic disease in infants.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Emma Guttman
University of Rochester, NY·Medicine & Clinical Research
Identify skin gene, protein and microbiome biomarkers that raise the risk of atopic dermatitis or support a healthy skin barrier, comparing high-risk Rochester infants with low-risk Old Order Mennonite infants.
Ryan Nelson
University of Minnesota, MN·Microbiology & Immunology·Early-career
Define how allergen-specific regulatory T cells that stay in the lung suppress Th2 resident memory T cells, characterizing their location, persistence, suppressive strength and gene expression in a house dust mite mouse model of asthma.
Katrina Abuabara
University of California-San Francisco, CA·Medicine & Clinical Research
Develop machine-learning models that predict persistent atopic dermatitis in late childhood from simple early-life factors, and compare their performance across birth cohorts in Uganda, Ecuador, and the United Kingdom.
The school
University of Cincinnati: 18 labs on PI Pages, $740M a year on research, 275 research doctorates a year.
Reach out
A start for your email. Fill in the brackets.