J. Mark Cline
Wake Forest University, NC·Medicine & Clinical Research
After a nuclear accident or radiation emergency, attention goes to the immediate sickness. Much of the lasting harm, though, appears months or years later as organ damage, scarring (fibrosis) and cancer.
- Fields
Medicine & Clinical Research
Physiology
Biology
- Topics
radiation injury
delayed effects of radiation exposure
acute radiation syndrome
- Grants
- 1 known grant, through Jul 2027
What they work on
- Identify and share patterns of late disease, such as diabetes, heart fibrosis, and kidney disease, in rhesus monkeys followed for years after whole-body radiation exposure.
- Identify genomic and biomarker characteristics that distinguish irradiated monkeys with different radiation-induced disorders, using shared blood, tissue, imaging and gene expression data.
- Assess the late effects of earlier mitigating treatments, such as blood-cell growth factors and antibiotics, given to monkeys after radiation exposure.
- Refine the survivor cohort to balance age, sex, radiation dose and mitigator type, which widens the range of conclusions that its data can support.
More about the research
These delayed effects are hard to study in people. This program maintains and studies the Radiation Survivor Cohort, a unique long-term population of rhesus monkeys that survived radiation exposure. Researchers use the cohort to learn which late diseases develop, who gets them, and why.
Why it matters
People exposed to radiation through accidents, attacks or medical treatment can face lasting harm, including diabetes, heart and kidney disease, and cancer. Long-term data from irradiated primates could help confirm which early biomarkers predict later disease. It could also show whether emergency treatments have late consequences and guide medical planning for radiation survivors.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Sally Amundson
Columbia University, NY·Medicine & Clinical Research
Test whether MIIST305, a drug that protects the gut from x-ray damage, also improves survival and reduces gut injury in rats exposed to nuclear-device-spectrum neutrons or ultra-high dose rate radiation.
Frederic Zenhausern
University of Arizona, AZ·Biomedical Engineering
Develop paper-compatible biodosimetry assays that distinguish radiation doses below 2 gray from 2 gray and above, using sandwich immunoassays for radiation-responsive leukocyte proteins and an amplification-free chemistry that detects DNA:RNA hybrids for transcripts.
Carmen Bergom
Washington University in St Louis, MO·Medicine & Clinical Research
Characterize the PET tracer [64Cu]Cu-DOTA-αvβ6-BP, which binds the scarring-linked integrin αvβ6, in mice given conventionally fractionated radiation, and identify blood biomarkers of radiation-induced pulmonary fibrosis.
The school
Wake Forest University: 27 labs on PI Pages, $345M a year on research, 54 research doctorates a year.
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