PIPages
Labs

Camilia Martin

Weill Medical College of Cornell University, NY·Medicine & Clinical Research

Babies born very early lose the steady supply of nutrients and protection they would have received in the womb, and breast milk is central to their care. That milk can also carry risks.

Fields

Medicine & Clinical Research

Microbiology & Immunology

Biochemistry

Topics

preterm infants

neonatology

cytomegalovirus

Grants
2 known grants, through Jul 2027

What they work on

  1. Measure the pharmacokinetics and virus-blocking power of an anti-CMV neutralizing antibody added to CMV-positive human milk, testing whether it can reduce infection and immune cell infiltration.
  2. Determine how cytomegalovirus reactivating in the breast changes the human milk lipidome, the full set of milk fats, and whether CMV-positive milk affects preterm infants' health outcomes.
  3. Identify how combined DHA and ARA feeding in extremely preterm infants changes fatty acid metabolism, including production of specialized pro-resolving mediators and oxylipins, in a 280-infant randomized trial.
  4. Determine how DHA and ARA supplementation from birth to 36 weeks postmenstrual age changes circulating markers of inflammation, organ development and organ integrity in extremely preterm infants.

More about the research

Feeding these infants safely and effectively is the shared theme of two projects: one on a virus that can pass through breast milk, and one on fats that the developing brain and eyes need.

Why it matters

Preterm infants depend on breast milk but are vulnerable to CMV passed through it and to missing fatty acids they would have received before birth. Adding neutralizing antibodies to CMV-positive milk could lower the risk of infection while keeping the nutrition of breast milk. The fatty acid trial could guide safer, more rational DHA and ARA feeding. Both projects aim to identify biomarkers for future clinical trials.

Known grants

From NIH and NSF research grants. Labs often have other funding we can't see.

CMV+ milk: morbidity risk & translational potential of neutralizing antibodies

NIH · Aug 2024 – Jul 2027

Metabolic mechanisms induced by enteral DHA and ARA supplementation in preterm infants

NIH · Jul 2022 – Apr 2027

Closest labs

Ginger Milne

University of Alabama at Birmingham, AL·Pharmacology

Identify how four specialized pro-resolving lipid mediators (RvE4, RvD1, RvD5 and maresin 2), molecules that help end inflammation, are chemically transformed using a laboratory model of human metabolism.

Zhenjia Wang

University at Buffalo, NY·Biomedical Engineering

Engineer liposomes built from ionizable cationic lipids to deliver docosahexaenoic acid (DHA), an omega-3 fatty acid, into neutrophils and release it efficiently once inside.

Matthew Harer

University of Wisconsin-Madison, WI·Medicine & Clinical Research

Test in a randomized trial whether an extra caffeine dose of 10 or 20 mg/kg raises kidney oxygen levels more than placebo in preterm infants under 30 weeks' gestation with low kidney oxygen measured by near-infrared spectroscopy.

The school

Weill Medical College of Cornell University: 35 labs on PI Pages, $1.6B a year on research, 59 research doctorates a year.

More about Weill Medical College of Cornell University

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