Edmund Tsui
University of California-Los Angeles, CA·Medicine & Clinical Research
Uveitis, inflammation inside the eye, is the fifth leading cause of blindness in the developed world. The forms that affect the middle and back of the eye are usually lifelong and cause the most visual loss.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
uveitis
uveitic macular edema
optical coherence tomography
- Grants
- 1 known grant, through Apr 2031
What they work on
- Identify which optical coherence tomography features, such as ellipsoid zone integrity, intraretinal hyperreflective foci and disorganization of retinal inner layers, predict response to therapy for uveitic macular edema across four completed randomized trials.
- Determine which OCT biomarkers correlate with baseline visual acuity and predict longitudinal changes in vision in patients with uveitic macular edema, using combined imaging and clinical data from the POINT, MERIT, ADVISE and FAST trials.
- Evaluate how OCT biomarkers, including photoreceptor layer and choroidal thickness, relate to inflammatory activity in intermediate, posterior and panuveitis and within selected specific uveitic diseases.
More about the research
A major obstacle in managing them is that clinicians lack objective measurements: deciding whether inflammation is active or treatment is working still rests heavily on subjective examination. This project looks for those objective measures in images that patients already receive.
Why it matters
Patients with chronic uveitis need lifelong monitoring, and clinicians currently have few objective ways to judge inflammation or predict who will respond to treatment. Validated OCT biomarkers, drawn from scans already performed in routine care at no added risk, could allow earlier detection of macular swelling, better tracking of disease activity, and treatment decisions that prevent permanent vision loss and disability.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Yan Li
Oregon Health & Science University, OR·Biomedical Engineering
Develop ultrahigh-resolution optical coherence tomography capable of imaging the aqueous humor at the front of the eye and the vitreous gel behind it.
Yali Jia
Oregon Health & Science University, OR·Biomedical Engineering
Build a 1-MHz, 120° wide-field, high-resolution OCTA system with GPU real-time processing that captures reliable retinal blood-flow images in a single scan, without stitching images together.
Yannis Paulus
Johns Hopkins University, MD·Biomedical Engineering
Upgrade a combined photoacoustic microscopy, optical coherence tomography and fluorescence microscopy system to image rabbit eyes in real time, without harming the eye.
The school
University of California-Los Angeles: 84 labs on PI Pages, $1.9B a year on research, 803 research doctorates a year.
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