Brittany Bannish
University of Central Oklahoma, OK·Mathematics & Statistics
After a wound heals, the body must dissolve the blood clot. Otherwise, a blocked vessel can cause a stroke or heart attack.
- Fields
Mathematics & Statistics
Biophysics
Biomedical Engineering
- Topics
blood clots
fibrin
clot lysis
- Grants
- 1 known grant, through Apr 2027
What they work on
- Test whether tension rearranges the fibrin gel before digestion, shrinking clot volume and expelling the enzymes that break clots down, using tensile testing, microscopy and modeling.
- Determine whether tension on fibrin fibers changes how clot-digesting enzymes bind to fibrin, combining time-resolved microscopy with mathematical models.
- Test whether tension rearranges fibers and the network during digestion so fibrin clears faster, and build a multiscale model that predicts clot breakdown from mechanical forces.
More about the research
A clot's scaffold is a mesh of fibrin fibers, and enzymes in the blood digest it in a process called fibrinolysis. Flowing blood and contracting platelets pull on these fibers, but no one knows well how this tension changes how fast clots break down.
Why it matters
Explaining how mechanical forces control clot breakdown could clarify why some clots fail to dissolve properly. That understanding may point to better ways to reduce the risk of strokes and heart attacks caused by blocked blood vessels. A predictive model linking force to clot breakdown could also guide future research.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Long Que
Iowa State University, IA·Biomedical Engineering
Develop a microfluidic chip with chamber arrays that links gut bacteria or microbiota to brain tissue models through an in vitro blood-brain barrier, mimicking two-way gut-brain communication.
Michael Levitt
University of Washington, WA·Biomedical Engineering
Run computational fluid dynamics simulations before and after treatment on a cohort of human cerebral aneurysms with known outcomes, and test which wall-based (Eulerian) and platelet-tracking (Lagrangian) measures predict success or failure.
Joseph Powers
University of Washington, WA·Biophysics·Early-career
Test whether loss of Filamin C (FLNC), a protein linking the heart cell's contractile units to its surroundings, disrupts inside-out force transmission by altering filament lattice geometry in mouse cardiomyocytes, using X-ray diffraction, atomic force microscopy and multiscale modeling.
The school
University of Central Oklahoma: 3 labs on PI Pages, $4M a year on research.
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