Chen Yuan Kam
University of California-Los Angeles, CA·Biology·Early-career
Blood vessels in the skin deliver oxygen and nutrients and help control body temperature. Much is known about how these vessels go wrong in skin disease.
- Fields
Biology
Physiology
Biomedical Engineering
- Topics
vascular remodeling
blood vessels
skin vasculature
- Grants
- 1 known grant, through Aug 2028
What they work on
- Track endothelial cell behaviors, such as migration within existing vessels, that prune and shape the skin vascular network in newborn mice, using longitudinal intravital imaging.
- Probe how adult skin vessels maintain their integrity by inflicting small, targeted laser ablation injuries on the vessel lining and following endothelial repair in live mice.
- Compare wound revascularization in newborn and adult mouse skin to identify the remodeling properties behind faster newborn repair, using live imaging and transcriptomics.
- Test how flow-guided endothelial cell rearrangement affects adult wound revascularization, using a genetic mutant mouse whose endothelial cells cannot orient to blood flow direction.
More about the research
Far less is known about how a healthy vessel network takes shape, maintains itself for a lifetime and repairs damage. A key open question is how the individual cells lining vessels coordinate their behavior across the whole network as blood flow changes.
Why it matters
This is largely basic science about how skin blood vessels develop, maintain themselves and heal. Because vessels are essential in every organ, the cellular rules it uncovers could inform work on vascular repair and wound healing elsewhere. Knowing why newborn skin re-grows vessels into wounds better than adult skin could eventually guide efforts to improve wound revascularization.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Merline Benny
University of Miami, FL·Medicine & Clinical Research
Test whether genetic deletion or drug inhibition of gasdermin D (GSDMD) protects newborn mice exposed to excess oxygen from vascular and cardiac dysfunction, measured in both newborn and adult mice.
Ibolya Rutkai-Green
Tulane University of Louisiana, LA·Physiology
Test whether reduced brain blood flow (hypoperfusion), produced in mice by narrowing both carotid arteries (BCAS), worsens age-related leakiness of the blood-brain barrier, using in vivo two-photon microscopy in young and old mice of both sexes.
Naoki Kaneko
University of California-Los Angeles, CA·Biomedical Engineering
Determine which endothelial cell (vessel-lining cell) signaling pathways are associated with unstable wall remodeling in human intracranial aneurysms, using tissue imaged by micro-CT and multiphoton microscopy.
The school
University of California-Los Angeles: 84 labs on PI Pages, $1.9B a year on research, 803 research doctorates a year.
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