Anthony Sochet
Johns Hopkins University, MD·Medicine & Clinical Research·Early-career
Critically ill children on breathing machines face a difficult trade-off. They have a high risk of blood clots in the veins or lung arteries, called venous thromboembolism (VTE), which can be life-threatening.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
venous thromboembolism
hospital-acquired VTE
blood clots
- Grants
- 1 known grant, through Dec 2029
What they work on
- Determine how the intensity of invasive mechanical ventilation affects functional fibrinolysis, the body's ability to break down clots, in critically ill children.
- Identify blood biomarkers of hospital-acquired venous thromboembolism risk in ventilated children, focusing on selected thromboinflammatory cytokines, immune signaling proteins linked to clotting.
- Discover plasma proteomic phenotypes, patterns across many blood proteins, that distinguish ventilated children who develop blood clots.
- Build an improved clot risk prediction model for ventilated children that combines fibrinolysis and clotting tests, ventilator settings, inflammatory cytokines and clinical risk factors.
More about the research
They also bleed more easily, so giving every child blood thinners is not safe. No validated tool tells doctors which ventilated children most need clot prevention. Building that tool is the goal of this project.
Why it matters
Children in intensive care on mechanical ventilation could benefit from a risk model that identifies who is most likely to develop dangerous blood clots. Such a model could separate them from children for whom blood thinners pose too much bleeding risk. It could guide future clinical trials of targeted clot prevention, and the biomarkers it uncovers may point to new treatment approaches.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Julie Jaffray
University of California-San Diego, CA·Medicine & Clinical Research·Early-career
Prospectively validate a pediatric hospital-acquired venous thromboembolism (VTE) risk assessment model from the CHAT Consortium, using a case-control design and electronic medical record review.
Charles Lowenstein
Johns Hopkins University, MD·Medicine & Clinical Research
Test whether BCOR, a gene-silencing protein, suppresses Factor VII production in liver cells by controlling the epigenetic complexes PRC1.1 and ATAC, which regulate how DNA is packaged and read.
Denise Hasson
New York University, NY·Medicine & Clinical Research·Early-career
Characterize baseline nutritional status in 200 high-risk pediatric ICU patients using dietary questionnaires, malnutrition screening, arm circumference, skinfold thickness, grip strength and muscle ultrasound, and test whether these risk subtypes predict acute kidney injury.
The school
Johns Hopkins University: 100 labs on PI Pages, $4.1B a year on research, 622 research doctorates a year.
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