Andrea Hevener
University of California-San Diego, CA·Physiology
Understanding diabetes and obesity requires measuring how a whole body handles fuel. This includes how it burns energy, responds to insulin, and how its mitochondria (the cell's energy-producing structures) work.
- Fields
Physiology
Medicine & Clinical Research
Biochemistry
- Topics
metabolism
diabetes
obesity
- Grants
- 1 known grant, through Jun 2028
What they work on
- Provide measurements of hormone sensitivity, body composition and energy balance in genetically engineered mice, including indirect calorimetry and glucose and insulin tolerance tests.
- Assess oxidative metabolism, exercise capacity and mitochondrial function and shape, so researchers can link genes to how cells and tissues burn fuel.
- Measure inflammatory signaling, circulating hormones, adipokines and cytokines, and diabetes complications, while maintaining a tissue biobank and a database of mouse phenotypes.
More about the research
Many of these measurements are technically demanding and are not offered by national testing centers. As a result, researchers who build genetically engineered mice to study a gene often cannot fully test what that gene does to metabolism.
Why it matters
The core helps diabetes and obesity researchers test how specific genes affect insulin action, energy use, mitochondrial function and diabetes complications in mice, tissues and cells. Making these measurements reliable and widely available may help move findings from mice toward human metabolic disease.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Kirk Habegger
University of Alabama at Birmingham, AL·Physiology
Provide expertise in selecting and using animal models, including genetically modified animals, for research on diabetes and cardiometabolic disease.
Absalon Gutierrez
University of Texas Health Science Center at Houston, TX·Medicine & Clinical Research
Identify molecular signatures of weight and energy-expenditure change after GLP-1 receptor agonist withdrawal using RNA sequencing and DNA methylation analysis of abdominal subcutaneous fat biopsies in 100 adults with obesity.
William Tamborlane
Yale University, CT·Medicine & Clinical Research
Provide shared infrastructure for complex human diabetes studies, such as insulin-glucose clamps, MRI and spectroscopy, PET scans, stable isotope infusions and indirect calorimetry, in adults and children.
The school
University of California-San Diego: 84 labs on PI Pages, $1.9B a year on research, 637 research doctorates a year.
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